William Van Etten,
Senior Scientific Consultant
As a PhD geneticist, Van Etten contributes the perspective of a scientist in helping clients solve their computer-aided research problems. Van Etten honed his informatics skills at the Whitehead Institute Center for Genome Research at MIT before co-founding BioTeam in 2002. Since then he has specialized in the development of informatics software with a keen eye toward ease of use.
Prior to graduate school, Van Etten owned and operated several restaurants in Massachusetts. He still does a lot of elaborate cooking and has been known to swap recipes with clients. Van Etten enjoys “home microbiology”; brewing beer, making wine and cheese. He was once a bee keeper but is presently merely a bee haver. Van Etten plays several musical instruments: piano, guitar, cello, ukulele and sings tenor/bass in the local choir.
- Web Development
- Organizational Assessments
- Strategic Planning
- Molecular Modeling
- Next Generation Sequencing
Van Etten received his Doctorate of Philosophy in Genetics at Indiana University in Bloomington, Indiana. Following his graduate research Bill was Senior Software Engineer at the Whitehead Institute Center for Genome Research where he contributed to the genetic mapping of the rat, and was the Head of Informatics for the Mouse Radiation Hybrid Mapping Project as well as Whitehead’s contribution to the SNP Consortium. Bill was involved with the generation of 2 million DNA sequences, and the discovery of 1.4 million Human SNPs; having developed and optimized novel algorithms for SNP discovery. He took these high-throughput computing research skills to Blackstone Computing as Principal Bioinformaticist where he designed, built and configured environments to support computer-aided research for life sciences.
- Van Etten WJ, Janssen GR. An AUG initiation codon, not codon-anticodon complementarity, is required for the translation of unleadered mRNA in Escherichia coli. Mol Microbiol. 1998 Mar;27(5): 987-1001. PMCID9535088.
- Steen RG, Kwitek-Black AE, Glenn C, Gullings-Handley J, Van Etten W, Atkinson OS, Appel D, Twigger S, Muir M, Mull T, Granados M, Kissebah M, Russo K, Crane R, Popp M, Peden M, Matise T, Brown DM, Lu J, Kingsmore S, Tonellato PJ, Rozen S, Slonim D, Young P, Jacob HJ. A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. Genome Res. 1999 Jun; 9(6):AP1-8. PMCID10400928.
- Van Etten WJ, Steen RG, Nguyen H, Castle AB, Slonim DK, Ge B, Nusbaum C, Schuler GD, Lander ES, Hudson TJ. Radiation hybrid map of the mouse genome. Nat Genet. 1999 Aug;22(4):384-7. PMCID10431245.
- Altshuler D, Pollara VJ, Cowles CR, Van Etten WJ, Baldwin J, Linton L, Lander ES. An SNP map of the human genome generated by reduced representation shotgun sequencing. Nature. 2000 Sep 28;407(6803):513-6. PMCID11029002.
- Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D; International SNP Map Working Group. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature. 2001 Feb 15;409(6822):928-33. PMCID11237013.
- Hudson TJ, Church DM, Greenaway S, Nguyen H, Cook A, Steen RG, Van Etten WJ, Castle AB, Strivens MA, Trickett P, Heuston C, Davison C, Southwell A, Hardisty R, Varela-Carver A, Haynes AR, Rodriguez-Tome P, Doi H, Ko MS, Pontius J, Schriml L, Wagner L, Maglott D, Brown SD, Lander ES, Schuler G, Denny P. A radiation hybrid map of mouse genes. Nat Genet. 2001 Oct;29(2):201-5. PMCID11586302.
- Krishnan K., Van Etten WJ, Janssen GR. Proximity of the start codon to a leaderless mRNA’s 5’- terminus is a strong positive determinant of ribosome binding and expression in Escherichia coli. Accepted by Journal of Bacteriology; August, 2010.